Nexium

Item	Count		Retail	Price	Order
Nexium 20 mg	30	capsules	$240.90	$200.75
Nexium 20 mg	90	capsules	$576.90	$480.75
Nexium 40 mg	30	capsules	$244.50	$203.75
Nexium 40 mg	90	capsules	$593.70	$494.75

BEFORE USING :

Some medicines or medical conditions may interact with nexium . INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking cilostazol, diazepam, digoxin, iron, itraconazole, ketoconazole, sucralfate, or vitamins with iron. Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you have liver disease. Contact your doctor or pharmacist if you have any questions or concerns about using nexium .

DIRECTIONS :

Follow the directions for using nexium provided by your doctor. SWALLOW WHOLE. DO NOT chew, or crush the capsule. Take nexium at least 1 hour before a meal, unless otherwise directed by your doctor. IF YOU HAVE DIFFICULTY SWALLOWING CAPSULES, you may open the capsule and sprinkle the contents on 1 tablespoon of applesauce. Mix the medicine with the applesauce and swallow immediately. The applesauce should not be hot and should be soft enough to swallow without chewing. Discard any uneaten applesauce/medicine mixture. nexium may be taken with antacids if your doctor has instructed you to take antacids. STORE nexium at room temperature at 77 degrees F (25 degrees C) in a tightly-closed container, away from heat, light, and moisture. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. IF YOU MISS A DOSE OF nexium , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

CAUTIONS :

BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using nexium during pregnancy. IT IS UNKNOWN IF nexium IS EXCRETED in breast-milk. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using nexium , check with your doctor or pharmacist to discuss the risks to your baby.

nexium Possible side effects :

SIDE EFFECTS, that may go away during treatment, include headache, constipation, cough, or diarrhea. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience throat pain, chest pain, severe stomach pain, or coffee-ground vomit. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

DRUG INTERACTIONS :

Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other.

IF YOU TAKE TOO MUCH :

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include confusion, drowsiness, blurred vision, fast heartbeat, nausea, excessive sweating, flushing, headache, and dry mouth.

ADDITIONAL INFORMATION :

If you are taking nexium for gastric ulcers or reflux disease, your symptoms should improve within 4 to 8 weeks. If your symptoms do not improve or if they become worse, contact your doctor. Do Not Share nexium with others for whom it was not prescribed. Do Not Use nexium for other health conditions. KEEP nexium out of the reach of children. If using nexium for an extended period of time, obtain refills before your supply runs out.

Drug Name: Nexium (esomeprazole magnesium)

What is Nexium?

How does Nexium work?

Each acid-producing cell contains millions of acid pumps. NEXIUM works by decreasing the acid produced by these acid pumps. As you can see in this drawing, NEXIUM turns off (deactivates) some of the pumps to keep acid production under control. By reducing acid production in the stomach, NEXIUM reduces the chance of acid backing up into the esophagus and causing reflux symptoms.

How to take Nexium:

Your healthcare professional will tell you how and when to take NEXIUM. NEXIUM is available as a capsule, which comes in different dosage strengths. Your healthcare professional will prescribe the dose that is right for you.

Taking NEXIUM should be part of your usual routine so that you do not forget to take it. NEXIUM capsules should be taken before meals and swallowed whole (the capsules should never be chewed or crushed). If you have a hard time swallowing capsules, you can empty a capsule into a tablespoon of applesauce. The applesauce should be eaten right away and never stored for later use. The pellets should not be chewed or crushed.

Do Not Use NEXIUM to treat any other medical conditions unless instructed by your healthcare professional. Never share NEXIUM with anyone else - it has been prescribed for you!

Nexium is a proton pump inhibitor (PPI) used to treat heartburn, or gastroesophageal reflux. It may be used in combination with two antibiotics to treat Helicobacter pylori (H. pylori) infection and duodenal ulcers. Nexium may also be used to treat other conditions as determined by your doctor. General Information about Nexuim

Nexium has been approved by the FDA for the relief of heartburn and other symptoms associated with gastroesophageal reflux disease (GERD) and for the healing of erosive esophagitis, a potentially serious condition associated with GERD. The FDA also approved Nexium for maintenance of healing of erosive esophagitis and, in combination with amoxicillin and clarithromycin, for the eradication of Helicobacter pylori infection in patients with duodenal ulcer disease.

Nexium is derived from Prilosec (omeprazole). Prilosec contains a racemic mixture of the D- and L- forms (isomers) of omeprazole. Nexium contains only one of the isomers. Both Prilosec and Nexium are known as proton pump inhibitors.

As many as 25 million adults experience heartburn on a daily basis. Although heartburn is the most common symptom of GERD, the condition is also often marked by other symptoms - such as a sour taste in the mouth or difficulty swallowing - related to the backing up of harsh stomach acid into the esophagus. When this acid reflux damages the lining of the esophagus, it may lead to a potentially more serious condition called erosive esophagitis that can lead to narrowing or ulceration of the esophagus.

Clinical Results

Four multicenter, double-blind, randomized trials evaluated the healing rates of Nexium 40 mg, Nexium 20 mg, and omeprazole 20 mg in subjects with endoscopically diagnosed erosive esophagitis. Healing rates were evaluated at week four and eight. At week eight, healing rates were higher with Nexium treatment compared to omeprazole in all four studies.

Two multicenter, randomized, double-blind, placebo-controlled 4-arm trials evaluated the long-term maintenance of healing of erosive esophagitis in patients taking Nexium. The trials included subjects with endoscopically confirmed, healed erosive esophagitis, and they evaluated Nexium 40 mg, 20 mg and 10 mg once-daily over six months of treatment. Subjects remained in remission significantly longer and the number of recurrences of erosive esophagitis was significantly less in subjects treated with Nexium compared to placebo.

Nexium's effectiveness in the resolution of GERD symptoms was evaluated in two Nexium multicenter, randomized, double-blind, placebo-controlled trials. These trials were conducted in a total of 717 subjects, and they compared four weeks of treatment with Nexium 20 mg or 40 mg once daily versus placebo. The percentage of subjects who were symptom-free of heartburn was significantly higher in the Nexium groups compared to placebo at all follow-up visits (weeks 1, 2 and 4).

In three European symptomatic GERD trials, no significant treatment related differences were observed between Nexium 20 mg and 40 mg and omeprazole 20 mg.

Nexium in combination with amoxicillan and clarithromycin was tested in two multicenter, randomized, double-blind trials for the eradication of Helicobacter pylori (H. pylori) in subjects with duodenal ulcer disease. H. pylori eradication rates at four weeks post-therapy were significantly higher in the Nexium plus amoxicillin and clarithromycin group than in a Nexium plus clarithromycin or Nexium alone group.

nexium Possible side effects:

Nexium can cause side effects. Some of these side effects are minor and usually do not require you to stop taking the medicine. Others may be more serious.

The most common side Nexium effects are:

•  Headache

•  Diarrhea

•  Abdominal Pains

Other serious stomach conditions may still exist. For a complete listing of all the side effects that have been reported with the use of Nexium, ask your healthcare professional to talk to you about the full important product information about Nexium.

Storage Instructions:

Keep Nexium out of the reach of children and always replace the bottle cap after use. Leave Nexium in the original package and protect the medicine from sunlight and moisture. Store Nexium at room temperature (between 59°F and 86°F or between 15°C and 30°C).

Side Effects

Side effects reported with Nexium use include (but are not limited to) the following:

•  Headache

•  Diarrhea

•  Abdominal pain

Safety and effectiveness have not yet been established in pediatric patients.

Please consult your physician for further information on side effects or to discuss the individual appropriateness of Nexium treatment.

Mechanism of Action

Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, esomeprazole blocks the final step in acid production, thus reducing gastric acidity. This effect is dose-related up to a daily dose of 20 to 40 mg and leads to inhibition of gastric acid secretion. (Nexium Prescribing Information)

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